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Our goal: to understand protein folding, misfolding, and related diseases

What is protein folding and how is folding linked to disease? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out these important functions, they assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, in many ways remains a mystery.

Moreover, when proteins do not fold correctly (i.e. "misfold"), there can be serious consequences, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, Huntington's, Parkinson's disease, and many Cancers and cancer-related syndromes.

You can help by simply running a piece of software. [email protected] is a distributed computing project -- people from through out the world download and run software to band together to make one of the largest supercomputers in the world. Every computer makes the project closer to our goals.

[email protected] uses novel computational methods coupled to distributed computing, to simulate problems thousands to millions of times more challenging than previously achieved.

[email protected] PS3 client now available.

CURRENT PROJECTS AND PROGRESS TO DATE:

* Alzheimer's Disease

* Cancer

* Huntington's Disease

* Osteogenesis Imperfecta

* Parkinson's Disease

* Ribosome & antibiotics

Your participation can help lead to a cure for these diseases.

Click here for free download.

What have we done so far? We have had several successes. You can read about them on our Science page, Results section, or go directly to our press and papers page.

Want to learn more? Click on the links on the left for downloads or more information. You can also download our Executive Summary, which is a PDF suitable for distribution. Also, you can learn more by watching recent seminars (Stanford BMI ; Xerox PARC). One can also help by donating funds to the project, via Stanford University

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Instructions for installation:

1. Download the application: http://www.stanford.edu/group/pandegroup/r...504-Console.exe

2. Open "My Computer"

3. Open "C:"

4. Create a folder named "folding"

5. Copy the application you downloaded to that folder, then double click it.

6. You will be prompted with this

# Windows Console Edition #####################################################
###############################################################################

                       [email protected] Client Version 5.04beta

                          http://folding.stanford.edu

###############################################################################
###############################################################################

Launch directory: C:\[email protected]
Executable: FAH504-Console.exe
Arguments: -config

[05:06:06] - Ask before connecting: No
[05:06:06] - User name: HotFoot (Team 40051)
[05:06:06] - User ID: 1F246BBF1D6613F0
[05:06:06] - Machine ID: 1
[05:06:06]
[05:06:06] Configuring [email protected]

User name [anonymous]?[/code] Pick a name and type it at that prompt
[code]Team Number [0]? 49518
Type 49518 and hit Enter
Launch automatically at machine startup, installing this as a
service (yes/no) [no]? yes[/code] Type yes and hit enter
[code]Ask before fetching/sending work (no/yes) [no]?
NO
Use Internet Explorer Settings (no/yes) [no]?
NO
Use proxy (yes/no) [no]?
NO
Allow receipt of work assignments and return of work results greater than
5MB in size (such work units may have large memory demands) (no/yes) [no]? yes[/code] YES
[code]Change advanced options (yes/no) [no]? yes

NO

After you make all your selections it will start downloading your first Work Unit (WU). The window will stay open until you reboot your machine and then you will never have to see it again.

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